Dr. Safiul Alam is interested in Experimental Organic Chemistry. His research group is currenly working on Transition Metal Catalyzed Coupling Reactions in presence of Organic Base to access valuable Heterocyclic Compounds and their application in Medicinal Chemistry and Material Sciences.   

Education

Post-Doctoral Research:

Universite Paris Descartes (Paris V), France (2009-2010),

National Central University (NCU) & National Tsing Hua University (NTHU), Taiwan (2007-2008). 

Ph. D.: Kalyani University (2006)

M. Sc.: University of Calcutta (2002)

B. Sc.: University of Clacutta (Ramakrishna Mission Vidyamindra, 2000)

Teaching Experience

Since October 2012 to till date

Industrial Experience

Two years R & D experience in CRO as Senior Research Scientist: 

Jubilant Chemsys, Noida, India (2010-2011)

TCG Lifesciences, Kolkata, India (2011-2012)

Field of Specialization

Organic Chemistry and Medicinal Chemistry

Courses Taught/Teaching

Spring Semester:

CH 512: Applied Organic Chemistry

CH 408: Chemistry of Natural Products

CH 492: Organic Chemistry Lab-I

CH 304: Organic Chemistry-III

CH 202: General Chemistry-IV

CH102: General Chemistry-II

Autumn Semester:

CH 509: Heterocyclic Chemistry

CH 515: Organic synthesis-I

CH 403: Advanced Organic Chemistry

CH 491: Advanced Chemistry Lab-I

CH 305: Organic Chemistry-II

CH 201: General Chemistry-III

CH103: Organic Chemistry-I

Research Area

• Synthetic Organic Chemistry
• Heterocyclic Chemistry
• Transition Metal Catalyzed Coupling Reactions 
• Bio-activity Study of Heterocyclic Compounds 
• Study of Physical Properties of Heterocyclic Compounds

Experience

• Postdoctoral Research, University Paris Descatres, Franch.
• Postdoctoral Research, NCU-NTHU,Taiwan, ROC.
• Doctoral and Postdoctoral Research, University of Kalyani,India.

Journal Papers Published

1. “Microwave-assisted synthesis of functionalized carbazoles via palladium-catalyzed aryl C–H activation and study of their interactions with calf-thymus DNA”, Safiul Alam*, Rejaul Karim, Aminur Khan, Asifur Rahaman Mallick, Nayim Sepay and Soumen Ghosh, Synth. Commun. 2022, 52, 1834-1855. DOI: https://doi.org/10.1080/00397911.2022.2116344
2. “One-Pot Multicomponent Reaction: A Highly Versatile Strategy for the Construction of Valuable Nitrogen-Containing Heterocycles”, Sibaji Nandi, Ramen Jamatia, Rajib Sarkar, Fillip Kumar Sarkar, Safiul Alam*, and Amarta Kumar Pal, ChemistrySelect 2022, 7, e202201901, 1 to 36. DOI: https://doi.org/10.1002/slct.202201901
3. “Copper-Catalyzed Preparation of Alkenylboronates and Arylboronates”, Safiul Alam*, Rejaul Karim, Aminur Khan, Amarta Kumar Pal and Antoine Maruani, Eur. J. Org. Chem. 2021, 6115-6160. DOI: https://doi.org/10.1002/ejoc.202100817  
4. "Mild and Efficient Synthesis of Functionalized Carbazoles via a DBU-Assisted Sequence Involving Cu- and Pd-Catalyzed Coupling Reactions" Aminur Khan, Rejaul Karim, Hamid Dhimane and Safiul Alam*, ChemistrySelect 2019, 4, 6598-6605.
5. “Novel derivatives of 1,2,3-triazole, cannabinoid-1 receptor ligands modulated gastrointestinal motility in mice.” Agata Szymaszkiewicz, Marta Zielinska, Kun Li, Mani Ramanathan, Safiul Alam, Duen-Ren Hou, Jakub Fichna and Martin Storr, Naunyn-Schmiedeberg's Arch Pharmacol 2018, 391, 435-444.
6. “Recent Development in the Orthoester Johnson-Claisen Rearrangement and Applications.” Safiul Alam* International Journal of Chemical Research 2016, 8, 173-194.
7. “A concise synthesis of Bengamide E and analogues via E-selective cross-metathesis olefination.” Safiul Alam and Hamid Dhimane, Synlett 2010, 19, 2923-2927.
8. “1,2,3-Triazole derivatives as new cannabinoid CB1 receptor antagonists.”  D. –R. Hou, Safiul Alam, T. –C. Kuan, M. Ramanathan, T. –P. Lin and M. –S. Hung. Bioorganic & Medicinal Chemistry Letters 2009, 19, 1022-1025.
9. “Regioselective Unusual Formation of Spirocyclic 4-{3'-Benzo(2',3'-ihydro)furo}-9-methyl-2,3,9-trihydrothiopyrano[2,3-b]indole by Acid Catalyzed Reaction of Enol ethers.” K. C. Majumdar and S. Alam and B. Chattopadhyay, Journal of Heterocyclic Chemistry 2009, 46, 62-68.
10. “Catalysis of the Claisen rearrangement.” K. C. Majumdar, Safiul Alam and B. Chattopadhyay, Tetrahedron 2008, 64, 597-643.
11. “Aluminium Chloride-Catalyzed Claisen Rearrangement: Synthesis of Polyheterocycles Containing Oxygen, Nitrogen, and Sulfur.” K. C. Majumdar, R. Islam and S. Alam, Synthetic Communications 2008, 38, 754-766.
12. “Regioselective synthesis of indole-annulated sulfur heterocycles by tri-n-butyltin hydride-mediated aryl radical cyclization.” K. C. Majumdar, P. Debnath, S. Alam and R. Islam, Journal of Sulfur Chemistry 2008, 29, 467-474.
13. “Thiol-mediated radical cyclization: regioselective formation of indole-annulated sulfur heterocycles by tandem cyclization.” K. C. Majumdar, P. Debnath, S. Alam and P. K. Maji, Tetrahedron Letters 2007, 48, 7031-7033.
14. “Regioselective Synthesis of 4-Aryloxymethylene-2,3,5-trihydrothiopyrano[3,2-b]indoles by the thio-Claisen Rearrangement of 3-(4’-Aryloxybut-2’-ynylthio)indoles.” K. C. Majumdar, S. Alam, S. Muhuri, Journal of Heterocyclic Chemistry 2007, 44, 1395-1399.
15. “Regioselective Unusual Formation of Spirocyclic 4-{2’-Benzo(2’,3’-dihydro)furo}-9-methyl-2,3,9-trihydrothiopyrano[2,3-b]indoles by 4-exo-trig Aryl Radical Cyclization and Rearrangement.” K. C. Majumdar and S. Alam, Organic Letters 2006, 8, 4059-4062.
16. “Regioselective Synthesis of 7-acetyl-11c-methyl-4b,5,7,11c-tetrahydro[1]benzofuro[2’,3’:4,5]thipyrano[2,3-b]indoles by sequential Claisen Rearrangement of 2-(4’-Aryloxybut-2’-ynylthio)-1-acetylindoles.” K. C. Majumdar and S. Alam, Journal of Chemical Research 2006, 281-285.
17. “Regioselective Synthesis of thieno[2,3-b]indoles by tandem cyclization involving sequential sigmatropic Rearrangements” K. C. Majumdar and S. Alam, Journal of Chemical Research 2006, 289-292.
18. “Regioselective Synthesis of Thieno[3,2-b]indoles by Tandem Cyclization of 1-Acetyl-3-(4’-Aryloxybut-2’-Ynylthio)Indole” K. C. Majumdar, S. Alam and S. Muhuri, Letters in Organic Chemistry 2006, 3, 250-252.

Books Published

1. Synthesis of Aryl-, Alkenyl-, Allyl-, Allenyl- and Propargylboronates by Environmentally Benign Copper Catalysts, by Dr. Safiul Alam, 2018.

ISBN: 978-81-936671-9-4

Awards

• Postdoctoral Fellowship, French Ministry of High Education and Research, Franch.
• Postdoctoral Fellowship, National Science Council, Govt. of Taiwan, Taiwan, ROC.
• Junior Research Fellowship (JRF) and Lecturership, NET-UGC-CSIR (Exam. Dec-2001), Govt. of India.
• Jonior Research Fellowship (JRF), TIFR (1^st Position), Mumbai, Govt. of India.
• Young Scientist Award, 2013

Ph.D. Thesis Guidance

Ph.D. students:

1. Rejaul Karim

2. Aminur Kham

3. Asifur Rahaman Mallick

MASTER Thesis Guidance

5th Year M.Sc. Project Students:

2014: Mr. Md. Imran Hossain Gazi, Topics: Project: Synthesis of Organic Compounds Having Medicinal Importance. Review: Structural Analysis of Bengamide Derivatives as Inhibitors of Methionine Aminopeptidages (MetAPs).

2016: Mr. Rejaul Karim, Topics: Project: Palladium Catalyzed C-C and C-N Cross Coupling Reactions of Iodobromobenzene. Review: Boronic Acid and its Derivatives: The Valuable Reagents in Organic Synthesis.

2017: (i) Mr. Sarower Rahaman, Topics: Project: Copper Catalyzed Synthesis of Biarylthioethers under Mild Conditions. Review: Palladium Catalyzed C-N Coupling Reactions.

(ii) Mr. Md Asrafuzzaman, Topics: Project: Cu-Catalyzed Coupling Reactions of Halophenols with Arylboronic Acids. Review: An introduction to alkaloids and their applications in pharmaceutical chemistry.

2018: (i) Mr. Abdur Raki, Topics: Project: A metal free synthesis of arylboronates from aromatic amines. Review: Transitionmetal catalyzed preparation of arylboronic acid derivatives from aryl halides and sulfonates.

(ii) Mr. Tousif Ali, Topics: Project: BDU-catalyzed O-arylation of 2-iodophenol followed by Pd-catalyzed C-C bond forming coupling reactions. Review: Transition metal catalyzed hydroamination reactions of alkynes and alkenes.

(iii) Mr. Mehebub Alam Mamun, Topics: Project: Pd-catalyzed C-C bond forming cross coupling. Review: Pd-, Cu-catalyzed Sonogashira coupling-cyclization reactions towards the preparation of heterocyclic compounds.

2019: (i) Mr. Wasim Enam, Topics: Project: Synthesis of indolo[3,2-b]carbazole from carbazole via Pd-catalyzed C-N and C-C bond forming coupling reactions. Review: Synthesis of linearly fused benzodipyrrole based organic materials.

(ii) Mr. Nurabul Mondal, Topics: Project: Synthesis of indolo[2,3-b]carbazole derivative from carbazole by Pd-catalyzed C-N and C-C coupling reactions. Review: Synthesis of indole derivatives through Pd-catalyzed carbometalation cyclization and Sonogashira coupling followed by cyclization process.

(iii) Mr. Anis Ahmed, Topics: Project: Synthesis of phenanthridiones from 2-iodo-N-arylbenzamides via Pd-catalyzed C-C coupling reactions. Review: A brief overview on different methods on the synthesis of carbazoles by first row transition metal catalysts.

(iv) Mr. Ashif Iqubal, Topics: Project: Synthesis of phenanthridin-6(5H)-ones via benzoylation of o-iodoanilines followed by Pd-catalyzed intramolecular arylation. Review: Synthesis of carbazole and its derivatives through late-transition metal catalyzed C-H functionalization.

Project Works

Principal Investigator (PI) of DST-SERB Project (3 years: 2014-2017)

Title: Transition metal-catalyzed coupling-cyclization cascade reactions toward the synthesis of fused heterocyclic compounds 

Membership Of Learned Societies

• Life Member: Chemical Research Society of India (CSIR), Indian Association for the Cultivation of Sciience (IACS).
• Member of Editorial Board: “World Research Journal of Organic Chemistry”, Bioinfo Publications.

• Reviewer: “Chemistry International”, Bosal Journals.

Orientation/Refresher/QIP CourseAttended/Organized

Orientation Programme: 58th Orientation Programme, UGC-HRDC, Jadavpur University. 

Refresher Course: Disaster Management and Environment, UGC-HRDC, Jadavpur University.

Seminar/Conference/Workshop

1. Symposium on Advances in Organic and Medicinal Chemistry (2009): “Concise Route Towards Natural Bengamide E and Analogues as Potential Inhibitors of Methionine Aminopeptidases” by S. Alam, at Universite Paris Descartes, France, 09-10.09. 2009.

2. Annual Chinese Chemical Society & ICCT joint Conference (ICCT-2007 International Chemical Conference): National Tsing Hua University, Taiwan, 13.12.2007.

3. National Symposium on Current Trends in Chemistry (2007): “Thiol-mediated radical cyclization: regioselective formation of indole-annulated sulfur heterocycles by tandem cyclization” by S. Alam, at University of Kalyani, India, 30–31.01.2007.

4. National Symposium on Advances in Chemistry and Environmental Impact (ACE-2006): “Regioselective Unusual Formation of Spirocyclic 4-{2′-Benzo(2′,3′-dihydro)furo-9-methyl-2,3,9-trihydrothiopyrano[2,3-b]indole by 4-exo-trig Aryl Radical Cyclization and Rearrangement” by S. Alam, at North-Eastern Hill University, India, 02 03.11.2006.

Other Notable Activities

Professional Responsibility:

1. Vice-chairman, Hostel Management Committee (HMC), Aliah University [Dec. 2019 - March 2022]

2. Chairman, Hostel Management Committee (HMC), Aliah University [March 2022 - till date]