Officiating HoD

Applied Bio-Chemistry Lab

Lab Webpage: https://sites.google.com/view/mhlab

The lab aims to find out novel therapeutics against cancer, specially by targeting various immune checkpoints exploiting the structural aspects of the cancer specific antigens. Moreover, ABC lab also focusses on understanding the genetic and biochemical basis of host pathogen interaction.  

Education

2012-2016                              

Ph.D. (Biotechnology), Aligarh Muslim University, India.

Thesis title: Effect of oleic acid complex of α-lactalbumin on mammalian erythrocyte membrane. Supervisor: Prof. M. Saleemuddin.

2011-2012                              

M.Phil. (Biotechnology), Aligarh Muslim University, India.

Thesis title: Studies on oleic acid complexes of some proteins with antitumor properties (Studies on BAMLET). Supervisor: Prof. M. Saleemuddin.

2008-2010                              

M.Sc. (Biotechnology), North Eastern Hill University, India

Dissertation title: Analysis of phenetic relationship among Neolissochilus hexagonolepis and five other cyprinids of Meghalaya and Assam using ISSR markers. Supervisor: Dr. M.A. Laskar.

2005-2008                              

B.Sc. (Zoology), Gauhati University, India.

Project title: “Monitoring the population trend of Greater Adjutant Stork (Leptoptilos dubius) from summer to winter seasons in Guwahati Municipal Area”. Funded by Rufford Small Grants Foundation, London through Aaranyak’s Student grant (2007-08). PI: Dr. Mridul Borthakur.

Industrial Experience

January 2011-April 2011

R & D Trainee at Bhat Biotech India Private Ltd. Bangalore under Biotech Industrial Training Programme of Biotech Consortium India Limited.

Field of Specialization

Cancer Biology, Protein Chemistry and Engineering, Membrane Biology, Computational Biology.

Courses Taught/Teaching

Biomolecules, Biophysics, Animal Diversity, Animal Behavior

Experience

July 2016 to September 2017       

Postdoctoral Research Associate (Department of Biotechnology, Govt. of India), Assam University, Silchar, India.

Conference Papers Published

1. Mehboob Hoque, Jyoti Gupta, M. Saleemddin (2013).“Ion channel mediated hemolysis of anucleated and nucleated erythrocytes by Bovine α-Lactalbumin Made Lethal to Tumor cells (BAMLET)” at the National Symposium on “Modern Trends in Human Diseases”organized by Indian Academy of Biomedical Sciences (IABS) and Department of Biochemistry, JN Medical College, AMU, Aligarh, India.

2. Munazza T. Fatima, Ejaj Ahmad, Mehboob Hoque, M. Owais, M. Saleemuddin (2013). “Plasma microparticles as potential drug/vaccine delivery candidates” at the National conference on “Nanoscience and Nanotechnology” conducted by Department of Applied Physics, Z. H. College of Engineering, AMU, Aligarh, India.

3. Mehboob Hoque, Munazza T. Fatima, Jyoti Gupta, M. Saleemuddin (2013). “Oleic Acid Plays the Seminal Role in the BAMLET-induced Erythrocyte Hemolysis” at the foundation day symposium on “Current Trends in Biotechnology”at Interdisciplinary Biotechnology Unit, AMU, Aligarh, India.

4. Mehboob Hoque, Jyoti Gupta, Pawan Gupta, M. Saleemuddin (2015). “HAMLET-like complexes with enhanced cytotoxicity” at Global Cancer Summit, 2015 at Indian Institute of Science, Bangalore, India.

5. Mehboob Hoque, Jyoti Gupta, M. Saleemuddin (2016). “BAMLET is depleted of oleic acid on interaction with cells” at the National Symposium on “Biomedical Sciences in 21^st Century and Beyond”organized by Indian Academy of Biomedical Sciences (IABS) and Department of Biochemistry, Medanta, the Medicity, Gurgaon, India.

Journal Papers Published

2024

1. Md Aminur Islam, Md Gulam Jilani, Mehboob Hoque, Safdar Ali (2024). Genome microsatellite signature analysis in Adenoviridae family of viruses. The Microbe. Volume 4, September 2024, 100157. doi: https://doi.org/10.1016/j.microb.2024.100157.

2. Arifa Khatun, Taslima Nasrin, Md Samim Hassan, Mehboob Hoque, Muddasarul Hoda, Safdar Ali (2024). A review on the nexus of autophagy genes from the perspective of polycystic ovary syndrome. Biology of the cell. doi: https://doi.org/10.1111/boc.202300069. IF 2.4

3. Chandan Gorain, Subhadeep Gupta, SS Mahafujul Alam, Mehboob Hoque, Andrey V. Karlyshev and Amirul Islam Mallick* (2024). Identification and functional characterization of putative ligand binding domain(s) of JlpA protein of Campylobacter jejuni. International Journal of Biological Macromolecules. IF 8.2 

4. Amit Pal, Aninda Dhar, Muhammad Aaqib Shamim, Isha Rani, Ram Rattan Negi, Aaina Sharma, Namrata Chatterjee, Anmol Goyal, Bandhan Kaur, Vincenzo Tondolo, Mauro Rongioletti, Subha Ranjan Samantaray, Mehbboob Hoque, Anil Pawar, Kalyan Goswami, Rosanna Squitti (2024). Selenium levels in colorectal cancer: A Systematic Review and Meta-Analysis of serum, plasma, and colorectal specimens. Journal of Trace Elements in Medicine and Biology. Volume 84, July 2024, 127429. doi: https://doi.org/10.1016/j.jtemb.2024.127429. IF 3.6

5. Taslima Nasrin, Md Samim Hassan, Muzaffar Iqbal, Amar Yousif, Mehboob Hoque, Nemat Ali, Safdar Ali (2024). Elucidating the evolution of monkeypox virus genomes through phylo-geo-network and haplogroup analysis. Journal of Genetic Engineering and Biotechnology. Volume 22, Issue 1, March 2024, 100346. doi: https://doi.org/10.1016/j.jgeb.2023.100346. IF 3.6 

6. Ashif Ahamed, Arijit Samanta, Syed Sahajada Mahafujul Alam, Showkat Ahmad Mir, Zarnain Jamil, Safdar Ali, Mehboob Hoque* (2024). Non-synonymous Mutations in VEGF Receptor Binding Domain Alters the Efficacy of Bevacizumab Treatment. Journal of Cellular Biochemistry. doi: 10.1002/jcb.30515. IF 4

7. Md Samim Hassan, Syed Sahajada Mahafujul Alam, Arijit Samanta, Mehboob Hoque*, Safdar Ali (2024). Codon usage patterns of the eleven SARS-CoV-2 variants with reference to the Wuhan sequence. Gene Reports. 101861. https://doi.org/10.1016/j.genrep.2023.101861. IF 1.3 

2023

8. Arijit Samanta, Ashif Ahamed, Syed Sahajada Mahafujul Alam, Safdar Ali, Mohd. Shahnawaz Khan, Abdulaziz M. Al-Amri, Shams Tabrez and Mehboob Hoque* (2023). Non-synonymous Single Nucleotide Polymorphisms in Human ACE2 Gene May Affect the Infectivity of SARS-CoV-2 Omicron Subvariants. Current Pharmaceutical Design. 29(36): 2891 – 2901. https://doi.org/10.2174/0113816128275739231106055502. IF 3.2  

9. Mehboob Hoque, Sneha Singh, Saadullah Khattak (2023) Editorial: Evolution, pathogenesis, host interactions and therapeutic strategies against monkeypox virus. Frontiers in Cellular and Infection Microbiology. Sec. Virus and Host, Volume 13 - 2023 | https://doi.org/10.3389/fcimb.2023.1303598

10. Md Gulam Jilani, Mehboob Hoque, Safdar Ali (2023). Microsatellite diversity and complexity in the viral genomes of the family Caliciviridae. Journal of Genetic Engineering and Biotechnology. 21, 140. doi: https://doi.org/10.1186/s43141-023-00582-x. IF 3.6

11. Ashif Ahamed, Mahmadul Hasan, Arijit Samanta, Syed Sahajada Mahafujul Alam, Zarnain Jamil, Safdar Ali, Mehboob Hoque* (2023). Prospective pharmacological potential of cryptotanshinone in cancer therapy. Pharmacological Research - Modern Chinese Medicine. 9: 100308. doi: https://doi.org/10.1016/j.prmcm.2023.100308. 

12. Syed Sahajada Mahafujul Alam, Arijit Samanta, Faizan Uddin, Safdar Ali, Mehboob Hoque* (2023). Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy. Pharmacological Reports. doi: https://doi.org/10.1007/s43440-023-00507-y. IF 4.4

13. Taslima Nasrin, Mehboob Hoque, Safdar Ali (2023). Systems biology of the genomes’ microsatellite signature of Orthopoxvirus including the Monkeypox virus. Comparative Immunology, Microbiology and Infectious Diseases, 98:102002. doi: https://doi.org/10.1016/j.cimid.2023.102002. IF 2.0

14. Iftikhar Ahmad, Mehboob Hoque, Syed Sahajada Mahafujul Alam, Torki A. Zughaibi, Shams Tabrez (2023). Curcumin and Plumbagin Synergistically Target the PI3K/Akt/mTOR Pathway: A Prospective Role in Cancer Treatment. International Journal of Molecular Sciences, 24(7):6651. doi: 10.3390/ijms24076651. IF 5.6

15. Arijit Samanta, Syed Sahajada Mahafujul Alam, Safdar Ali, Mehboob Hoque* (2023). Evaluating the transmission feasibility of SARS-CoV-2 Omicron (B.1.1.529) variant to 143 mammalian hosts: Insights from S protein RBD and host ACE2 interaction studies. Functional & Integrative Genomics, 23(1):36. doi: 10.1007/s10142-023-00962-z. IF 2.9

16. Mehboob Hoque, Arijit Samanta, Syed Sahajada Mahafujul Alam, Torki A. Zughaibi, Mohammad Amjad Kamal, Shams Tabrez (2023). Nanomedicine-based immunotherapy for Alzheimer's Disease. Neuroscience & Biobehavioral Reviews, 144: 104973. https://doi.org/10.1016/j.neubiorev.2022.104973. IF 8.2 

17. Taslima Nasrin, Mehboob Hoque, SafdarAli (2023). Microsatellite signature analysis of twenty-one virophage genomes of the family Lavidaviridae. Gene, 851: 147037. doi: https://doi.org/10.1016/j.gene.2022.147037. IF 3.5

2022

18. Zarnain Jamil, Arif Uddin, Syed Sahajada Mahafujul Alam, Arijit Samanta, Nojood Altwaijry, Mohd Ahmar Rauf, Safdar Ali, Mohd Shahnawaz Khan, Muhammad Nadeem Asghar, Mehboob Hoque* (2022). Analysis of the Compositional Features and Codon Usage Pattern of Genes Involved in Human Autophagy. Cells, 11(20), 3203; doi: https://doi.org/10.3390/cells11203203. IF 6.0

19. Shams Tabrez, Azhar Khan, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Torki Zughaibi (2022). Investigating anticancer efficacy of biogenic synthesized MgONPs: In vitro analysis. Frontiers in Chemistry, 10:970193. doi: https://doi.org/10.3389/fchem.2022.970193. IF 5.5

20. Shams Tabrez, Torki A Zughaibi, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Azhar U Khan (2022). Targeting Glutaminase by Natural Compounds: Structure-Based Virtual Screening and Molecular Dynamics Simulation Approach to Suppress Cancer Progression. Molecules, 27 (15), 5042. doi: https://doi.org/10.3390/molecules27155042. IF 4.6

21. Shams Tabrez, Azhar U Khan, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Torki A Zughaibi (2022). Biosynthesis of ZnO NPs from pumpkin seeds’ extract and elucidation of its anticancer potential against breast cancer. Nanotechnology Reviews, 11 (1), 2714-2725. doi: https://doi.org/10.1515/ntrev-2022-0154. IF  6.739 

22. Shams Tabrez, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Torki A Zughaibi, Azhar U Khan (2022). Identification of anticancer bioactive compounds derived from Ficus sp. by targeting Poly [ADP-ribose] polymerase 1 (PARP-1). Journal of King Saud University - Science, 34(5), 102079. doi: https://doi.org/10.1016/j.jksus.2022.102079. IF  3.8

23. Arijit Samanta, Syed Sahajada Mahafujul Alam, Safdar Ali, Mehboob Hoque* (2022). Analyzing the interaction of human ACE2 and RBD of spike protein of SARS-CoV-2 in perspective of Omicron variant. EXCLI Journal, 21: Doc610. doi: https://doi.org/10.17179/excli2022-4721. IF 4.6

24. Munazza T Fatima, Zeyaul Islam, Ejaj Ahmad, Mehboob Hoque, Marriam Yamin (2022). Plasma Bead Entrapped Liposomes as a Potential Drug Delivery System to Combat Fungal Infections. Molecules, 27 (3), 1105. doi: https://doi.org/10.3390/molecules27031105. IF 4.6

2021

25. Syed Sahajada Mahafujul Alam, Faizan Uddin, Farheen B. Khan, MA Kamal, Mehboob Hoque* (2021). Therapeutic and Pharmacological Potential of Tanshinones against Lung Cancer: A Systematic Review. Phytomedicine Plus, 2 (1), 100202. doi: https://doi.org/10.1016/j.phyplu.2021.100202. 

26. Mohammad Azam Ansari, Farheen Badrealam Khan, Haaris Ahsan Safdari, Ahmad Almatroudi, Mohammad A. Alzohairy, Mohammadreza Safdari, Mehran Amirizadeh, Suriya Rehman, Mohammad Javed Equbal, Mehboob Hoque* (2021). Prospective therapeutic potential of Tanshinone IIA: An updated overview. Pharmacological Research, 164: 105364. doi: https://doi.org/10.1016/j.phrs.2020.105364. IF 9.3  

2020

27. Jyoti Gupta, Haris A Safdari, Mehboob Hoque* (2020). Nanoparticle mediated cancer immunotherapy. Seminars in Cancer Biology, 69: 307-324. doi: https://doi.org/10.1016/j.semcancer.2020.03.015 . IF 14.5

2019

28. Jyoti Gupta, Mehboob Hoque, Md Fahim Ahmad, Rizwan Hasan Khan, M Saleemuddin, (2019). Acid pH promotes bispecific antibody formation by the redox procedure. International Journal of Biological Macromolecules, 125: 469-477, doi: 10.1016/j.ijbiomac.2018.12.063. IF 8.2

2018

29. Mehboob Hoque, Safdar Ali, Muddasarul Hoda, (2018). Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus. International Journal of Biological Macromolecules, 118: 2237-2244, doi: 10.1016/j.ijbiomac.2018.07.091. IF 8.2

30. Munazza Tamkeen Fatima, Ejaj Ahmad, Mehboob Hoque (2018). Effective antigen delivery via dual entrapment in erythrocytes and autologous plasma beads. Journal of Drug Targeting, 26:162-171, doi: 10.1080/1061186X.2017.1350859. IF 5.016

2017

31. Mehboob Hoque, Jyoti Gupta, M. Saleemuddin, (2017). Augmenting the Cytotoxicity of Oleic Acid-Protein Complexes: Potential of Target-Specific Antibodies. Biochimie, 137:139-146. doi: 10.1016/j.biochi.2017.03.013. IF 3.9

2016

32. Jyoti Gupta, Mehboob Hoque, Masihuz Zaman, Rizwan hasan Khan, M. Saleemuddin (2016). A detergent-based procedure for the preparation of IgG-like bispecific antibodies in high yield. Scientific Reports, 6:39198, doi: 10.1038/srep39198. IF 4.996 

33. Mehboob Hoque, Jyoti Gupta, Gulam Rabbani, Rizwan Hasan Khan, M. Saleemuddin (2016). Behaviour of Oleic acid-Depleted Bovine Alpha-Lactalbumin Made LEthal to Tumor cells (BAMLET). Molecular BioSystems, 12(6):1871-80. doi: 10.1039/c5mb00905g. IF 2.9

2015

34. Ejaj Ahmad, Munazza T Fatima, Mehboob Hoque, Mohammad Owais, Mohammed Saleemuddin (2015). Fibrin matrices: The Versatile Therapeutic Delivery Systems. International Journal of Biological Macromolecules, 81: 121–136. doi: 10.1016/j.ijbiomac.2015.07.054. IF 8.2

35. Mehboob Hoque, Ravikanth Nanduri, Jyoti Gupta, Sahil Mahajan, Pawan Gupta, M. Saleemuddin (2015). Oleic acid complex of bovine α-lactalbumin induces eryptosis in human and other erythrocytes by a Ca2+-independent mechanism. Biochim Biophys Acta-General Subjects, 1850 (9): 1729-1739. doi: 10.1016/j.bbagen.2015.04.009. IF 3

2013

36. Mehboob Hoque, Sandeep Dave, Pawan Gupta, Mohammed Saleemuddin (2013). Oleic Acid May Be the Key Contributor in the BAMLET-induced Erythrocyte Hemolysis and Tumoricidal Action. PloS ONE 8(9): e68390. doi: 10.1371/journal.pone.0068390. IF 3.752 

Books Published

1. Saadullah Khattak, Mehboob Hoque, Snaha Singh (2023) Evolution, pathogenesis, host interactions and therapeutic strategies against monkeypox virus. Frontiers in Cellular and Infection Microbiology, Frontiers in Public Health. ISSN 1664-8714; ISBN 978-2-8325-3801-2; DOI 10.3389/978-2-8325-3801-2.

Book Chapters

2024

1. Md Gulam Jilani, Mehboob Hoque, Shams Tabrez, Safdar Ali (2024) The genetic basis of neurodegenerative disorders: Implications in Alzheimer’s disease. Book Title: A New Era in Alzheimer’s Research: Pathogenesis, Prevention, and Treatment. ISBN: 978-0-443-15540-6

2. Md Samim Hassan, Taslima Nasrin, Anshu Vishwakarma, Mehboob Hoque, Safdar Ali (In Press) Systems Biology at a Glance. Book Title: Systems Biology and In-Depth Applications for Unlocking Diseases. Elsevier ISBN: 9780443223266 

3. Ashif Ahamed, Arijit Samanta, Syed Sahajada Mahafujul Alam, Zarnain Jamil, Safdar Ali, Mehboob Hoque* (In Press) High Throughput Data: Single Nucleotide Polymorphisms (SNP) in depth. Book Title: Systems Biology and In-Depth Applications for Unlocking Diseases.  Elsevier ISBN: 9780443223266 

4. Taslima Nasrin, Md Samim Hassan, Anshu Vishwakarma, Mehboob Hoque, Safdar Ali (In Press) Systems Virology. Book Title: Systems Biology and In-Depth Applications for Unlocking Diseases.  Elsevier ISBN: 9780443223266 

5. Syed Sahajada Mahafujul Alam, Arijit Samanta, Zarnain Jamil, Safdar Ali, Mehboob Hoque* (In Press) Systems Vaccinology. Book Title: Systems Biology and In-Depth Applications for Unlocking Diseases.  Elsevier ISBN: 9780443223266  

6. Zarnain Jamil, Ashif Ahamed, Arijit Samanta, Syed Sahajada Mahafujul Alam, Safdar Ali, Mehboob Hoque* (In Press) Systems Biology of Cancer. Book Title: Systems Biology and In-Depth Applications for Unlocking Diseases.  Elsevier ISBN: 9780443223266

2023

7. Syed Sahajada Mahafujul Alam, Arijit Samanta, Zakia Sultana, Zarnain Jamil, Safdar Ali, Mehboob Hoque* (2023) Liposome-based nanomedicines for cancer immunotherapy. Nanomedicine in Cancer Immunotherapy. ISBN 978-0-443-18770-4, DOI: 10.1016/B978-0-443-18770-4.00017-2.  

8. Zakia Sultana, Zarnain Jamil, Arijit Samanta, Syed Sahajada Mahafujul Alam, Safdar Ali, Mehboob Hoque* (2023) Current status, challenges, and future perspectives of nanomedicine-based cancer immunotherapy. Nanomedicine in Cancer Immunotherapy ISBN 978-0-443-18770-4, DOI: 10.1016/B978-0-443-18770-4.00015-9.   

9. Taslima Nasrin, Md Samim Hassan, Arijit Samanta, Mehboob Hoque and Safdar Ali (2023). The historical aspects of the SARS-CoV-2 virus and the ensuing pandemic. Linking Neuroscience and Behavior in COVID-19. https://doi.org/10.1016/B978-0-323-95650-5.00035-5.   

10. Arijit Samanta, Md Samim Hassan, Taslima Nasrin, Syed Sahajada Mahafujul Alam, Zarnain Jamil, Harpal S. Buttar, Safdar Ali and Mehboob Hoque* (2023) Different variants of SARS-CoV-2. Linking Neuroscience and Behavior in COVID-19. https://doi.org/10.1016/B978-0-323-95650-5.00053-7.  

11. Mirajul Islam, Taslima Nasrin, Arijit Samanta, Safdar Ali, Harpal S. Buttar and Mehboob Hoque* (2023) Lateral flow assay for SARS-CoV-2 infection: Uses and limitations. In: Linking Neuroscience and Behavior in COVID-19. https://doi.org/10.1016/B978-0-323-95650-5.00039-2.  

2021

12. Faizan Uddin, Mehboob Hoque* (2021). Non-Flavonoids Targeting Cancer Stem Cells: A Promising Therapeutic Avenue for Cancer Treatment. In: Tabrez S., Imran Khan M. (eds) Polyphenols-based Nanotherapeutics for Cancer Management. Springer, Singapore. https://doi.org/10.1007/978-981-16-4935-6_8

2019

13. Jyoti Gupta, Mehboob Hoque* (2019). Immunotherapy in Alzheimer’s Disease. In: Ashraf G., Alexiou A. (eds) Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease. Springer, Singapore. 271-293, doi: 10.1007/978-981-13-9636-6_14

Invited Lectures

Membership Of Learned Societies

1. Member, Indian Academy of Biomedical Sciences (IABS).
2. Life Member, Indian Science Congress
3. Life Member, Indian Biophysical Society

Orientation/Refresher/QIP CourseAttended/Organized

Other Notable Activities

Editorial Board Member of E Chronicon Proteomics and Bioinformatics