Nanobiotechnology is an interdisciplinary research domain that deals with designing, synthesis, and application of particles of sizes ranging between 1-500 nanometres in diameter. Nanoparticles and nanocomposites have wide range of applications in biomedical field that ranges between diagnosis, imaging and therapy. We at NAP LAB, are trying to address the limited bioavailability of the various therapeutic molecules by enhancing the cellular uptake of drug-loaded nanoparticles by surface functionalization of the same. Biopolymers from natural sources are being explored for potential synthesis of biodegradable and biocompatible nanoparticles that has significant drug payload.

Applied phytochemistry is a subject that deals with the extraction, isolation, identification, and application of wide range of compounds from various plant sources. Among the most commonly known phytochemicals is Quinine, an important alkaloid isolated form the bark of cinchona tree, is an important anti-malarial compound. Similarly, there exists a huge trove of potential phytochemicals in diverse plant sources that is influenced by geographical, climatic and seasonal variations. At NAP lab, we try understand the molecular action of mechanism of these phytochemicals with therapeutic potential against various diseases, especially diabetes and cancer. This domain of research contributes to the scientific foundation of various traditional folk medicine, that otherwise lacks modern scientific validation.

Researchers at NAP Lab are expected to broaden their technical skills with techniques such as chromatography, spectroscopy, cell culture handling, molecular biology techniques, and computational biology.

Education

Teaching Experience

9 years as on 03.06.2026

Field of Specialization

Nanobiotechnology

Applied phytochemistry

Courses Taught/Teaching

1. Metabolism 

2. Biotechniques 

3. Biostatistics

4. Bioinformatics

5. Genetics/Microbial genetics

6. Molecular biology 

7. Biosafety and bioethics

8. Advanced Cell Biology

Research Area

1. Biopolymer based nanoparticles as therapeutic, theragnostic, and drug delivery system
2. Phytochemicals extraction, identification, and delineation of its molecular mechanism of action
3. Application of nanobiotechnology in agriculture.

Experience

Conference Papers Published

1. Presented a poster on “Influence of stabilizers on production of Disulfiram loaded nanoparticles and their anti-cancer potential” at International Conference, Biomaterials-2014, organized by IIT, New Delhi, in October 2014.

Journal Papers Published

1. Sultana, Z., Ahamed, A., Hoda, M., Ali, S., & Hoque, M. (2026). Prospects and challenges in intracellular delivery of therapeutic proteins. Pharmacological Reports 2026, 1–28. https://doi.org/10.1007/S43440-026-00855-5 

2. ---

   Biswas, M., ul Hoda, M., & Das, S. (2025). An investigation on in vitro anti-oxidant, anti-malarial and enzyme inhibitory activities of a few Indian Piper species and their metabolite profiling with in silico analysis. Proceedings of the Indian National Science Academy 2025 92:1, 92(1), 272–292. https://doi.org/10.1007/s43538-025-00411-4

3. Hazra, A., Hoda, M., Jethwa, M., Saha, A., & Das, S. (2025). Metabolomic Based Insight Reveals a few Metabolites at Various Germination Stages of Black Rice, Demonstrating Potential Efficacy Against Dementia and Other Neurodegenerative Conditions. Applied Biochemistry and Biotechnology 2025 198:1, 198(1), 226–251. https://doi.org/10.1007/S12010-025-05471-2

4. Gurung, S., Sarmin, M., & Hoda, M. (2025). Aqueous Precipitate of Methanolic Extract of Bergenia ciliata Leaves Demonstrate Photoirradiation-Mediated Dual Property of Inhibition and Enhancement of Silver Nanoparticles Synthesis. Colloids and Interfaces, 10(1), 5. https://doi.org/10.3390/COLLOIDS10010005/S1

5. Perveen, S., Gurung, S., Sarmin, M., & Hoda, M. (2025). Antioxidant activity, metal-chelation, and photoirradiation mediated enhanced green synthesis of silver nanoparticles by the aqueous extract of the bark of Xylocarpus granatum. Sustainable Chemistry One World, 6, 100059. https://doi.org/10.1016/J.SCOWO.2025.100059

6. Sarmin, M., Gurung, S., Sarkar, S., Das, S., & Hoda, M. (2024b). White LED light-based photocatalysis enhances the green synthesis of silver nanoparticles by Trigonella foenum-graecum seeds’ aqueous extract. Nano-Structures & Nano-Objects, 37, 101091. https://doi.org/10.1016/J.NANOSO.2024.101091

7. Sarmin, M., Gurung, S., Sarkar, S., Das, S., & Hoda, M. (2024a). Photocatalysis-enhanced synthesis and stabilization of silver nanoparticles by methanol-based phytochemicals extract of Trigonella foenum-graecum seeds. JCIS Open, 15, 100116. https://doi.org/10.1016/J.JCISO.2024.100116

8. Gurung, S., Sarmin, M., & Hoda, M. (2024). Implications of White Light-Emitting Diode-Based Photoirradiation on Green Synthesis of Silver Nanoparticles by Methanol- and Aqueous-Based Extracts of Bergenia ciliata Leaves. Nanomaterials 2024, Vol. 14, Page 1327, 14(16), 1327. https://doi.org/10.3390/NANO14161327

9. Chatterjee, J., Hoda, M. U., & Das, S. (2024). In vitro screening of Triphala, its compositions and identification of a few phenolic compounds to determine their antioxidant, anti-malarial and hepatoprotective properties: a GC/MS-assisted metabolomics study. Chemical Papers, 78(1), 409–433. https://doi.org/10.1007/S11696-023-03098-3/METRICS

10. Khatun, A., Nasrin, T., Hassan, M. S., Hoque, M., Hoda, M., & Ali, S. (2024). A review on the nexus of autophagy genes from the perspective of polycystic ovary syndrome. Biology of the Cell, 116(7), e2300069. https://doi.org/10.1111/BOC.202300069

11. Sanaul Islam, M., Hoque, A., Mohamed Yusuf Baig, K., Sarmin, M., Kole, G. K., Hoda, M., & Akhtarul Alam, M. (2024). A zwitterionic probe for ratiometric fluorescent detection of aluminium(III) ion in aqueous medium and its application in bioimaging. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 311, 124005. https://doi.org/10.1016/J.SAA.2024.124005

12. Bhattacharya, S., Perris, A., Jawed, J. J., & Hoda, M. (2023). Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action. Pharmacological Research - Modern Chinese Medicine, 6, 100233. https://doi.org/10.1016/J.PRMCM.2023.100233

13. Saidul, S., Das, S., & Hoda, M. (2023). Evaluation of Nonconventional Extraction Methods of Resveratrol from Various Plant Sources - A Brief Review. Current Green Chemistry, 10(2), 131–142. https://doi.org/10.2174/2213346110666230517114652

14. Sarkar, S., Hoda, M. U., & Das, S. (2023). Anti-melanogenic, antioxidant potentialities and metabolome classification of six Ocimum  species: Metabolomics and in-silico approaches. Trends in Phytochemical Research, 7(1), 30–50. https://doi.org/10.30495/TPR.2023.1977617.1317

15. Subramanian, S., Pajaniradje, S., Tumdam, R., Hoda, M., Dasgupta, A., & Rajagopalan, R. (2023). Indole curcumin combats metastatic HBV-positive hepatocellular carcinoma by inhibiting cell proliferation, migration, and matrix metalloproteinase-9 activity. Journal of Cancer Research and Therapeutics, 19(2), 265–272. https://doi.org/10.4103/JCRT.JCRT_1256_21

16. Poornima, K., Francis, A. P., Hoda, M., Eladl, M. A., Subramanian, S., Veeraraghavan, V. P., El-Sherbiny, M., Asseri, S. M., Hussamuldin, A. B. A., Surapaneni, K. M., Mony, U., & Rajagopalan, R. (2022). Implications of Three-Dimensional Cell Culture in Cancer Therapeutic Research. Frontiers in Oncology, 12, 891673. https://doi.org/10.3389/FONC.2022.891673/XML/NLM

17. Perris, A., Bhattacharya, S., Jawed, J. J., & Hoda, M. (2021). Oncotherapeutic Application of Resveratrol-based Inorganic Nanoparticles. Pharmaceutical Nanotechnology, 9(4), 271–280. https://doi.org/10.2174/2211738509666210906164727

18. Velan, A., & Hoda, M. (2021). In-silico comparison of inhibition of wild and drug-resistant Haemonchus contortus β-tubulin isotype-1 by glycyrrhetinic acid, thymol and albendazole interactions. Journal of Parasitic Diseases, 45(1), 24–34. https://doi.org/10.1007/S12639-020-01274-W/METRICS

19. Sufi, S. A., Hoda, M., Pajaniradje, S., Mukherjee, V., Coumar, S. M., & Rajagopalan, R. (2020). Enhanced drug retention, sustained release, and anti-cancer potential of curcumin and indole-curcumin analog-loaded polysorbate 80-stabilizied PLGA nanoparticles in colon cancer cell line SW480. International Journal of Pharmaceutics, 588, 119738. https://doi.org/10.1016/J.IJPHARM.2020.119738

20. Hoda, M. (2020). Potential Alternatives to Conventional Cancer Therapeutic Approaches: The Way Forward. Current Pharmaceutical Biotechnology, 22(9), 1141–1148. https://doi.org/10.2174/1389201021666201016142408

21. Ahmad, I., & Hoda, M. (2020b). Molecular mechanisms of action of resveratrol in modulation of diabetic and non-diabetic cardiomyopathy. Pharmacological Research, 161, 105112. https://doi.org/10.1016/J.PHRS.2020.105112

22. Ahmad, I., & Hoda, M. (2020a). Attenuation of diabetic retinopathy and neuropathy by resveratrol: Review on its molecular mechanisms of action. Life Sciences, 245, 117350. https://doi.org/10.1016/J.LFS.2020.117350

23. Hoda, M., Sufi, S. A., Cavuturu, B., & Rajagopalan, R. (2018). Stabilizers influence drug–polymer interactions and physicochemical properties of disulfiram-loaded poly-lactide-co-glycolide nanoparticles. Future Science OA, 4(2), FSO263. https://doi.org/10.4155/fsoa-2017-0091

24. Hoque, M., Ali, S., & Hoda, M. (2018). Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus. International Journal of Biological Macromolecules, 118, 2237–2244. https://doi.org/10.1016/J.IJBIOMAC.2018.07.091

25. Shakya, G., Balasubramanian, S., Hoda, M., & Rajagopalan, R. (2018). Inhibition of metastasis and angiogenesis in Hep-2 cells by wheatgrass extract – an in vitro and in silico approach. Toxicology Mechanisms and Methods, 28(3), 205–218. https://doi.org/10.1080/15376516.2017.1388460

26. Hoda, M., Cavuturu, B. M., Iqbal, S., Shakya, G., & Rajagopalan, R. (2017). Disulfiram and disulfiram-loaded poly-[lactide-co-glycolic acid] nanoparticles modulate metastatic markers and proteasomal activity in hepatocarcinoma Hep3b cell line. European Journal of Nanomedicine, 9(3–4). https://doi.org/10.1515/ejnm-2017-0013

27. Hoda, M., Pajaniradje, S., Shakya, G., Mohankumar, K., & Rajagopalan, R. (2016). Anti-proliferative and apoptosis-triggering potential of disulfiram and disulfiram-loaded polysorbate 80-stabilized PLGA nanoparticles on hepatocellular carcinoma Hep3B cell line. Nanomedicine: Nanotechnology, Biology and Medicine, 12(6), 1641–1650. https://doi.org/10.1016/J.NANO.2016.02.013

28. Hoda, M., Sufi, S. A., Shakya, G., Kumar, K. M., & Rajagopalan, R. (2015). Influence of stabilizers on the production of disulfiram-loaded poly(lactic-co-glycolic acid) nanoparticles and their anticancer potential. Therapeutic Delivery, 6(1), 17–25. https://doi.org/10.4155/tde.14.99

29. Shakya, G., Manjini, S., Hoda, M., & Rajagopalan, R. (2014). Hepatoprotective role of kaempferol during alcohol- And pufa-induced oxidative stress. Journal of Basic and Clinical Physiology and Pharmacology, 25(1), 73–79. https://doi.org/10.1515/JBCPP-2013-0051/MACHINEREADABLECITATION/RIS

30. Durairaj, V., Hoda, M., Shakya, G., Babu, S. P. P., & Rajagopalan, R. (2014). Phytochemical screening and analysis of antioxidant properties of aqueous extract of wheatgrass. Asian Pacific Journal of Tropical Medicine, 7S1(S1), S398–S404. https://doi.org/10.1016/S1995-7645(14)60265-0

Books Published

Role of Phenolic Phytochemicals in Diabetes Management, 2019, Springer Singapore, ISSN 978-981-13-8996-2; https://doi.org/10.1007/978-981-13-8997-9

Hoda, Muddasarul, Hemaiswarya, Shanmugam, Doble, Mukesh

Ph.D. Thesis Guidance

Registered PhD Scholars: 04 (as of 03.06.2026)

Project Works

Project title: Protein-based surface functionalization of silibinin-loaded poly-lactide co-glycolic acid nanoparticles and its implications on liver cancer cell lines. Duration: April 2025- March 2026. Budget: Rs.1.5 Lakh. Memo No. AU/REG/RDC/0011/025, Project ID. AURDC/2024-25/BIO/06.

Membership Of Learned Societies

• Life Member, Indian Science Congress

Other Notable Activities

SPOC Coordinator; SWAYAM NPTEL Local Chapter for Aliah University 

Chairman: University Committee for West Bengal Health Scheme

Member: University Maintenance Committee

Member: Board of Studies, Department of Biological Sciences, Aliah University