Nanobiotechnology is an interdisciplinary research domain that deals with designing, synthesis, and application of particles of sizes ranging between 1-500 nanometres in diameter. Nanoparticles and nanocomposites have wide range of applications in biomedical field that ranges between diagnosis, imaging and therapy. We at NAP LAB, are trying to address the limited bioavailability of the various therapeutic molecules by enhancing the cellular uptake of drug-loaded nanoparticles by surface functionalization of the same. Biopolymers from natural sources are being explored for potential synthesis of biodegradable and biocompatible nanoparticles that has significant drug payload.

Applied phytochemistry is a subject that deals with the extraction, isolation, identification, and application of wide range of compounds from various plant sources. Among the most commonly known phytochemicals is Quinine, an important alkaloid isolated form the bark of cinchona tree, is an important anti-malarial compound. Similarly, there exists a huge trove of potential phytochemicals in diverse plant sources that is influenced by geographical, climatic and seasonal variations. At NAP lab, we try understand the molecular action of mechanism of these phytochemicals with therapeutic potential against various diseases, especially diabetes and cancer. This domain of research contributes to the scientific foundation of various traditional folk medicine, that otherwise lacks modern scientific validation.

Researchers at NAP Lab are expected to broaden their technical skills with techniques such as chromatography, spectroscopy, cell culture handling, molecular biology techniques, and computational biology.

Education

Field of Specialization

Nanobiotechnology

Applied phytochemistry

Courses Taught/Teaching

1. Metabolism and Plant biochemistry

2. Biotechniques and biostatistics

3. Bioinformatics

4. Genetics/Microbial genetics

5. Molecular biology 

6. Biosafety and bioethics

Research Area

1. Biopolymer based nanoparticles as therapeutic, theragnostic, and drug delivery system
2. Phytochemicals extraction, identification, and delineation of its molecular mechanism of action against various diseases.
3. Application of nanobiotechnology in agriculture.

Experience

Conference Papers Published

1. Presented a poster on “Influence of stabilizers on production of Disulfiram loaded nanoparticles and their anti-cancer potential” at International Conference, Biomaterials-2014, organized by IIT, New Delhi, in October 2014.

Journal Papers Published

1. Md Sanaul Islam, Anamika Hoque, K. Mohamed Yusuf Baig, Monalisha Sarmin, Goutam Kumar Kole, Muddasarul Hoda, Md. Akhtarul Alam, A zwitterionic probe for ratiometric fluorescent detection of aluminium(III) ion in aqueous medium and its application in bioimaging, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 311, 2024, 124005, ISSN 1386-1425. https://doi.org/10.1016/j.saa.2024.124005
2. Monalisha Sarmin, Sourav Gurung, Sreerupa Sarkar, Susmita Das, Muddasarul Hoda, White LED light-based photocatalysis enhances the green synthesis of silver nanoparticles by Trigonella foenum-graecum seeds’ aqueous extract, Nano-Structures & Nano-Objects, Volume 37, 2024, 101091, ISSN 2352-507X. https://doi.org/10.1016/j.nanoso.2024.101091
3. Chatterjee, J., Hoda, M.U. & Das, S. In vitro screening of Triphala, its compositions and identification of a few phenolic compounds to determine their antioxidant, anti-malarial and hepatoprotective properties: a GC/MS-assisted metabolomics study. Chemical Papers, 78, 409–433 (2024). https://doi.org/10.1007/s11696-023-03098-3
4. Subramanian S, Pajaniradje S, Tumdam R, Hoda M, Dasgupta A, Rajagopalan R. Indole curcumin combats metastatic HBV-positive hepatocellular carcinoma by inhibiting cell proliferation, migration, and matrix metalloproteinase-9 activity. Journal of Cancer Research and Therapeutics. 2023 Jan-Mar;19(2):265-272. doi: 10.4103/jcrt.jcrt_1256_21.
5. Saidul Sk, Das Susmita and Hoda Muddasarul*, Evaluation of Nonconventional Extraction Methods of Resveratrol from Various Plant Sources - A Brief Review, Current Green Chemistry 2023; 10 (2). https://dx.doi.org/10.2174/2213346110666230517114652
6. Sanchari Bhattacharya, Angela Perris, Junaid JSanchari Bhattacharya, Angela Perris, Junaid Jibran Jawed, Muddasarul Hoda. Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action, Pharmacological Research - Modern Chinese Medicine, Volume 6, 2023, 100233. https://doi.org/10.1016/j.prmcm.2023.100233.
7. Sarkar, S., Hoda, M., & Das, S. (2023). Anti-melanogenic, antioxidant potentialities and metabolome classification of six Ocimum species: Metabolomics and in-silico approaches. Trends in Phytochemical Research, 7(1), 30-50. doi: 10.30495/tpr.2023.1977617.1317
8. Poornima K, Francis AP, Hoda M, Eladl MA, Subramanian S, Veeraraghavan VP, El-Sherbiny M, Asseri SM, Hussamuldin ABA, Surapaneni KM, Mony U, Rajagopalan R. Implications of Three-Dimensional Cell Culture in Cancer Therapeutic Research. Frontiers in Oncology. 2022 May 12;12:891673. doi: 10.3389/fonc.2022.891673.
9. Velan A, Hoda M. In-silico comparison of inhibition of wild and drug-resistant Haemonchus contortus β-tubulin isotype-1 by glycyrrhetinic acid, thymol and albendazole interactions. Journal of Parasitic Diseases, 2021 Mar;45(1):24-34. doi: 10.1007/s12639-020-01274-w.
10. Hoda M. Potential Alternatives to Conventional Cancer Therapeutic Approaches: The Way Forward. Current Pharmaceutical Biotechnology, 2021;22(9):1141-1148. doi: 10.2174/1389201021666201016142408
11. Perris A, Bhattacharya S, Jawed JJ, Hoda M. Oncotherapeutic Application of Resveratrol-based Inorganic Nanoparticles. Pharmaceutical Nanotechnology. 2021;9(4):271-280. doi: 10.2174/2211738509666210906164727.
12. Sufi SA, Hoda M, Pajaniradje S, Mukherjee V, Coumar SM, Rajagopalan R. Enhanced drug retention, sustained release, and anti-cancer potential of curcumin and indole-curcumin analog-loaded polysorbate 80-stabilizied PLGA nanoparticles in colon cancer cell line SW480. International Journal of Pharmaceutics. 2020;588:119738. doi:10.1016/j.ijpharm.2020.119738
13. Ahmad I, Hoda M. Molecular mechanisms of action of resveratrol in modulation of diabetic and non-diabetic cardiomyopathy. Pharmacological Research. 2020;161:105112. doi:10.1016/j.phrs.2020.105112
14. Ahmad I, Hoda M. Attenuation of diabetic retinopathy and neuropathy by resveratrol: Review on its molecular mechanisms of action. Life Sciences. 2020;245:117350. doi:10.1016/j.lfs.2020.11735
15. Hoque M, Safdar Ali, Hoda M (2018) Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus. International Journal of Biological Macromolecules, 118:2237-2244 https://doi.org/10.1016/j.ijbiomac.2018.07.091
16. Hoda M, Cavuturu B, Iqbal S, Shakya G, Rajagopalan R. Disulfiram &   Disulfiram-loaded poly- [lactide-co-glycolic acid] nanoparticles modulate metastatic markers & proteasomal activity in hepatocarcinoma hep3b cell line. (European Journal of Nanomedicine, 2017, AOP, https://doi.org/10.1515/ejnm-2017-0013)
17. Hoda M, Cavuturu B, Sufi SA, Rajagopalan R. Stabilizers Influence Drug-Polymer Interactions and Physiochemical properties of Disulfiram-Loaded PLGA Nanoparticles. (Future Science OA, 2017, https://doi.org/10.4155/fsoa-2017-0091)
18. Shakya G, Balasubramanian S, Hoda M & Rajagopalan R. Inhibition of metastasis and angiogenesis in Hep-2 cells by wheatgrass extract – an in vitro and in silico approach. (Toxicology Mechanisms & Methods, 2017, DOI: 10.1080/15376516.2017.1388460)
19. Hoda M, Pajaniradje S, Shakya G, Mohankumar K, Rajagopalan R. Anti-proliferative and apoptosis-triggering potential of Disulfiram and Disulfiram-loaded Polysorbate 80-stabilized PLGA nanoparticles on hepatocellular carcinoma Hep3B cell line. (Nanomedicine:NBM, 2016;12:1641-1650)
20. Hoda M, Sufi SA, Shakya G, Kumaravel M, Rajagopalan R. Influence of stabilizers on production of disulfiram loaded PLGA nanoparticles and their anti-cancer potential. Therapeutic delivery. 2015;6(1):17-25 
21. Durairaj V, Hoda M, Shakya G, Babu SP, Rajagopalan R. Phytochemical screening and analysis of antioxidant properties of aqueous extract of wheatgrass. Asian Pacific Journal of Tropical Medicine. 2014;7S1:S398-404
22. Shakya G, Durairaj V, Hoda M, Rajagopalan R. RP-HPLC analysis & oxidative stress mediated cytotoxic effect of methanol extract of wheat grass by modulating Nrf2-level in Hep-2 cells. International Journal of  pharma Sciences. 2015;5(1):897-903
23. Shakya G, Manjini S, Hoda M, Rajagopalan R. Hepatoprotective role of kaempferol during alcohol- and â��PUFA- Induced oxidative stress. Journal of Basic Clinical Physiology and Pharmacology. 2014;25(1):73-79
24. Rukkumani Rajagopalan, Shakya G, Pajaniradje S, Hoda M, Durairaj V. GC-MS Analysis, In Vitro Antioxidant and Cytotoxic Studies of Wheatgrass Extract. American Journal of Phytomedicine and Clinical Therapeutics. 2014;2(7):877-893

Books Published

Role of Phenolic Phytochemicals in Diabetes Management, 2019, Springer Singapore, ISSN 978-981-13-8996-2; DOI: 10.1007/978-981-13-8997-9 

Hoda, Muddasarul, Hemaiswarya, Shanmugam, Doble, Mukesh

Ph.D. Thesis Guidance

Registered PhD Scholars: 04 (as of April 2024)

Membership Of Learned Societies

• Life Member, Indian Science Congress

Other Notable Activities

Coordinator; SWAYAM NPTEL Local Chapter for Aliah University 

Chairman: University Committee for West Bengal Health Scheme